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The role of post-mortem investigations in determining the cause of Sudden Unexpected Death in Infancy (SUDI)
  1. MARTIN A WEBER (m.weber{at}ich.ucl.ac.uk)
  1. Institute of Child Health, University College London, and Great Ormond Street Hospital for Children, United Kingdom
    1. MICHAEL T ASHWORTH
    1. Great Ormond Street Hospital for Children, United Kingdom
      1. R Anthony RISDON
      1. Great Ormond Street Hospital for Children, United Kingdom
        1. JOHN C HARTLEY
        1. Great Ormond Street Hospital for Children, United Kingdom
          1. MARIAN MALONE
          1. Great Ormond Street Hospital for Children, United Kingdom
            1. NEIL J SEBIRE (sebirn{at}gosh.nhs.uk)
            1. Institute of Child Health, University College London, and Great Ormond Street Hospital for Children, United Kingdom

              Abstract

              Introduction: Several autopsy protocols have been suggested for investigating sudden unexpected deaths in infancy (SUDI). The aim of this study is to provide data on the utility of such post-mortem investigations from a large paediatric autopsy series in order to inform future policy.

              Methods: Retrospective analysis of >1,500 consecutive post-mortem examinations carried out by specialist paediatric pathologists at a single centre during a 10-year period according to a common autopsy protocol that included the use of detailed ancillary investigations. SUDI was defined as the sudden unexpected death of an infant aged 7 to 365 days. All data capture and cause of death classification were carried out according to defined criteria.

              Results: Of 1,516 paediatric post-mortem examinations, 546 presented as SUDI. In 202 infants (37%) death was explained by the autopsy findings. The other 344 cases (63%) remained unexplained. Of the explained deaths, over half (58%) were infective, most commonly due to pneumonia (22%). The component of the post-mortem examination which primarily determined the final cause of death was histological examination in 92 infants (46%), macroscopic examination in 61 (30%), microbiological investigations in 38 (19%), and clinical history in 10 (5%).

              Conclusion: This constitutes the largest single-institution autopsy study of SUDI. Ten years on from the CESDI SUDI studies, the ascertainment of a cause of death at autopsy has improved. However, with almost two thirds of SUDI remaining unexplained, alternative and/or additional diagnostic techniques are required to further improve detection rates of identifiable causes of death at autopsy.

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