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The value of MR spectroscopy in tumour imaging
  1. Andrew C Peet (acpeet{at}doctors.org.uk)
  1. University of Birmingham, United Kingdom
    1. Theodoros N Arvanitis (t.arvanitis{at}bham.ac.uk)
    1. University of Birmingham, United Kingdom
      1. Dorothee P Auer (dorothee.auer{at}nottingham.ac.uk)
      1. Nottingham University Hospitals, United Kingdom
        1. Nigel P Davies (nigel.davies{at}bch.nhs.uk)
        1. University Hospital Birmingham, United Kingdom
          1. Darren Hargrave (darren.hargrave{at}rmh.nhs.uk)
          1. Royal Marsden Hospital NHS Foundation Trust, United Kingdom
            1. Franklyn A Howe (howefa{at}sghms.ac.uk)
            1. St George's, University of London, United Kingdom
              1. Tim Jaspan (tim.jaspan{at}nuh.nhs.uk)
              1. Nottingham University Hospitals, United Kingdom
                1. Martin O Leach (martin{at}icr.ac.uk)
                1. Institute of Cancer Research, Sutton, United Kingdom
                  1. Donald Macarthur (donald.macarthur{at}nuh.nhs.uk)
                  1. Nottingham University Hospitals, United Kingdom
                    1. Lesley MacPherson (lesley.macpherson{at}bch.nhs.uk)
                    1. Birmingham Children's Hospital NHS Foundation Trust, United Kingdom
                      1. Paul S Morgan (paul.morgan{at}nottingham.ac.uk)
                      1. Nottingham University Hospitals, United Kingdom
                        1. Kal Natarajan (kal.natarajan{at}uhb.nhs.uk)
                        1. Univesity Hospital Birmingham NHS Foundation Trust, United Kingdom
                          1. Geoffrey S Payne (gsp{at}icr.ac.uk)
                          1. Institute of Cancer Research, London, United Kingdom
                            1. Dawn Saunders (dawn.saunders5{at}btinternet.com)
                            1. Great Ormond Street Hospital, London, United Kingdom
                              1. Richard G Grundy (richard.grundy{at}nottingham.ac.uk)
                              1. Nottingham University Hospitals, United Kingdom

                                Abstract

                                Magnetic resonance (MR) imaging plays a key role in the management of many childhood tumours. There is increasing interest in extending these investigations to MR techniques that give information on tumour biology in vivo.

                                Magnetic resonance spectroscopy (MRS) is one such method which provides information on tissue biochemistry. Promising results have been obtained from many preclinical and clinical studies leading to an expectation that MRS will play a valuable clinical role. However, the role of MRS is not yet well defined and there is a paucity of data from multi-centre clinical trials.

                                In this review we concentrate on MRS in paediatric oncology, providing some general guidance on current applications and outlining areas which need to be developed further.

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