Magnetic resonance (MR) imaging plays a key role in the management of many childhood tumours. There is increasing interest in extending these investigations to MR techniques that give information on tumour biology in vivo.
Magnetic resonance spectroscopy (MRS) is one such method which provides information on tissue biochemistry. Promising results have been obtained from many preclinical and clinical studies leading to an expectation that MRS will play a valuable clinical role. However, the role of MRS is not yet well defined and there is a paucity of data from multi-centre clinical trials.
In this review we concentrate on MRS in paediatric oncology, providing some general guidance on current applications and outlining areas which need to be developed further.