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Weight gain with Pizotifen therapy
  1. Graham L Briars (g.briars{at}doctors.org.uk)
  1. West Suffolk Hospital, United Kingdom
    1. Sarah E Travis (saratravis{at}yahoo.co.uk)
    1. West Suffolk Hospital, United Kingdom
      1. Binu Anand (binuanand{at}doctors.org.uk)
      1. West Suffolk Hospital, United Kingdom
        1. Anne M Kelly (amk25{at}doctors.org.uk)
        1. West Suffolk Hospital, United Kingdom

          Abstract

          Objective: To describe the characteristics of weight gain occurring on children treated for migranous conditions with pizotifen.

          Design: Retrospective case note review

          Setting: West Suffolk Hospital between 1999 and 2003

          Patients: 405 clinic attendances of 121 children receiving Pizotifen treatment

          Main outcome measures: Rates of change in weight for age z-score between successive outpatient appointments were used to detect excessive weight gain.

          Results: The mean rate of weight z-score increase for 105 patients receiving a constant dosage in 181 intervals between appointments was 0.79 standard deviations per year compared with 0.11 standard deviations per year for height z-score increases. The rate of weight z-score increase was not correlated with pizotifen dose per kg (r-.0.08), per m2 (r=-0.05) or initial BMI (r=-0.04). Mean rates of z-score increase were similar in patients with a satisfactory and unsatisfactory therapeutic responses.

          Conclusions: Excess weight gain in Pizotifen therapy is not predicted by drug dosage or therapeutic response within the range of doses used in clinical practice.

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