Arch Dis Child doi:10.1136/adc.2007.128579

Vitamin D Supplementation in Early Childhood and Risk of Type 1 Diabetes: a Systematic Review and Meta-analysis

  1. Christos S Zipitis (czipitis{at}
  1. Central Manchester and Manchester Children's University Hospitals, United Kingdom
    1. Anthony k Akobeng (tony.akobeng{at}
    1. Booth Hall Children's, United Kingdom
      • Published Online First 13 March 2008


      Objectives: To assess whether vitamin D supplementation in infancy reduces risk of type 1 diabetes in later life.

      Design: Systematic review and meta-analysis. Data sources: Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles.

      Main outcome measure: Development of type 1 diabetes.

      Inclusion criteria: Controlled trials and observational studies which had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes.

      Results: Five observational studies met the inclusion criteria; no randomised controlled trials were found. 4 of the 5 included studies were case control studies and the fifth study was a cohort study. Meta-analysis of data from the case control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis. There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes. Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes.

      Conclusion: Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.