Article Text

This article has a correction. Please see:

other Versions

PDF
Neonatal intrahepatocellular lipid
  1. Louise Thomas (louise.thomas{at}imperial.ac.uk)
  1. Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, United Kingdom
    1. Sabita Uthaya (s.uthaya{at}imperial.ac.uk)
    1. Division of Medicine, Chelsea & Westminster Campus, Imperial College London, United Kingdom
      1. Vimal Vasu (v.vasu{at}imperial.ac.uk)
      1. Division of Medicine, Chelsea & Westminster Campus, Imperial College London, United Kingdom
        1. John P McCarthy (john.mccarthy{at}imperial.ac.uk)
        1. Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, United Kingdom
          1. Peter McEwan (p.mcewan{at}imperial.ac.uk)
          1. Division of Medicine, Chelsea & Westminster Campus, Imperial College London, United Kingdom
            1. gavin Hamilton (dr_g_hamilton{at}yahoo.co.uk)
            1. Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, United Kingdom
              1. Jimmy D Bell (jimmy.bell{at}imperial.ac.uk)
              1. Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, United Kingdom
                1. Neena Modi (n.modi{at}imperial.ac.uk)
                1. Division of Medicine, Chelsea & Westminster Campus, Imperial College London, United Kingdom

                  Abstract

                  There is increasing evidence that preterm birth is a risk factor for the development of adiposity associated disease though the pathophysiological basis in unclear. <BR>We have previously shown that preterm infants have increased internal abdominal (visceral) adiposity by term. In adults increased internal adiposity is associated with elevated intrahepatocellular lipid (IHCL). <BR>We measured IHCL using 1H NMR spectroscopy in 26 infants (8 healthy preterm-at-term and 18 term-born) and compared values with a reference group of 32 adults.<BR> There was no significant difference between adult and term-born IHCL values. In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH2/water median (interquartile range): preterm 1.69 (1.04, 3.529), term 0.21 (0, 0.535) and adult 0.55 (0.08, 1.57).

                  • Fatty Liver
                  • Infant, Newborn
                  • Intrahepatocellular lipid

                  Statistics from Altmetric.com

                  Request permissions

                  If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

                  Linked Articles

                  • Miscellanea
                    BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health