Objectives:To review the causes of vertically transmitted HIV since the introduction of universal offer and recommendation of first trimester HIV testing in the UK.
Design:Retrospective case note review.
Setting:A tertiary referral hospital with a PICU in London providing family centred care for HIV.
Subjects:All 25 infants diagnosed with HIV between 1 January 2001 and 31 December 2005.
Main outcome measures:Antenatal HIV testing, clinical presentation and outcome.
Results:Twenty-one of the 25 cases received antenatal care in the UK. Twelve mothers had not had an antenatal HIV test, four were diagnosed antenatally, whilst five had had a negative HIV test on antenatal booking, implying seroconversion during pregnancy. When mothers had not been diagnosed antenatally, infants presented with severe infections, which were fatal in 6 cases. The majority (65%) have long term neurological sequelae.
Conclusion:HIV seroconversion in pregnancy is an important cause of infant HIV in the UK.
- vertical transmission