Article Text

other Versions

PDF

Primary ciliary dyskinesia
  1. Andrew Bush (a.bush{at}rbht.nhs.uk)
  1. Royal Brompton & Harefield NHS Trust, United Kingdom
    1. Rahul Chodhari
    1. GOSH, United Kingdom
      1. Nicola Collins
      1. Royal Brompton Hospital, United Kingdom
        1. Fiona Copeland
        1. Primary Ciliary Dyskinesia Family Support Group, United Kingdom
          1. Pippa Hall
          1. Royal Brompton Hospital, United Kingdom
            1. Jonny Harcourt
            1. Chelsea and Westminster Hospital, United Kingdom
              1. Mohamed Hariri
              1. Charing Cross Hospital, United Kingdom
                1. Claire Hogg
                1. Royal Brompton Hospital, United Kingdom
                  1. Jane Lucas
                  1. Southampton University Hospitals NHS Trust, United Kingdom
                    1. Hannah M Mitchison
                    1. UCL Institute of Child Health, United Kingdom
                      1. Christopher O'Callaghan
                      1. Leicester Royal Infirmary & University of Leicester, United Kingdom
                        1. Gill Phillips
                        1. Leeds Metropolitan University, United Kingdom

                          Abstract

                          Primary ciliary dyskinesia (PCD) is usually inherited as an autosomal recessive, and in classical form presents with upper and lower respiratory tract infection, and mirror image arrangement in around 50% cases. It is becoming appreciated that dysfunction of cilia is implicated in a wider spectrum of disease, including polycystic liver and kidney disease, central nervous system problems including retinopathy and hydrocephalus, and biliary atresia. Cilia are complex structures, containing more than 250 proteins, but recent studies have begun to locate PCD genes scattered throughout the genome. Screening tests for PCD include nasal nitric oxide and in vivo tests of ciliary motility such as the saccharin test. Specific diagnosis requires examination of cilia by light and electron microscopy, with epithelial culture in doubtful cases. This is only available in supra-regional centres, which have recently been centrally funded by NCG in order to provide a comprehensive, free diagnostic service in England. Treatment is unfortunately not evidence based, since there are no randomised controlled clinical trials in this condition, and recommendations are largely extrapolated from cystic fibrosis and other suppurative lung diseases.

                          • airway inflammation
                          • ciliopathy
                          • nitric oxide
                          • primary ciliary dyskinesia

                          Statistics from Altmetric.com

                          Request permissions

                          If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.