Objective: To assess the hypothesis that magnesium deficiency is associated with elevated high-sensitivity C-reactive protein (hsCRP) levels.
Design: Community based cross-sectional study.
Setting: Fourth-hundred eighty-eight apparently healthy children aged 10-13 years were randomly enrolled from Durango, city in northern Mexico, through a two-stage cluster sampling.
Main outcome measures: Serum magnesium and hsCRP levels, lipid profile, glucose, and insulin levels.
Results: A total of 109 (22.3%) and 101 (20.7%) children had elevated hsCRP concentrations and low serum magnesium levels; among them 87.1% exhibited both. Children who had both elevated hsCRP levels (2.45 ± 10.6 mg/L) and hypomagnesemia (1.3 ± 0.3 mg/dl), exhibit the highest fasting glucose (96.0 ± 13.9 mg/dl), insulin (13.6 ± 7.5 µU/ml), and triglycerides (131.5 ± 43.5 mg/dl) as well as the lowest HDL-cholesterol (46.4 ± 9.0 mg/dl) levels. The adjusted multivariate logistic regression analysis, showed a strong association between low serum magnesium and high hsCRP levels (odds ratio 4.1; CI95% 1.3-10.8).
Conclusions. Magnesium depletion is independently associated to elevated hsCRP levels, suggesting that hypomagnesemia and low-grade inflammation are interactive risk factors.
- C-reactive protein
- risk factors