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Nasal swabs for detection of respiratory syncytial virus RNA in children
  1. Matti Waris (matti.waris{at}utu.fi)
  1. University of Turku, Finland
    1. Terho Heikkinen (terho.heikkinen{at}utu.fi)
    1. Turku University Hospital, Finland
      1. Riikka Osterback (riikka.osterback{at}utu.fi)
      1. University of Turku, Finland
        1. Tuomas Jartti (tuomas.jartti{at}utu.fi)
        1. Turku University Hospital, Finland
          1. Olli Ruuskanen (olli.ruuskanen{at}tyks.fi)
          1. Turku University Hospital, Finland

            Abstract

            Nasal swab offers a sensitive sampling method for the detection of respiratory viruses in children. Respiratory syncytial virus (RSV) is an exception and it is detected more often in nasopharyngeal aspirates (NPA) than in nasal swabs when it is searched for by immunoassays or viral culture (1–2). Therefore, more laborous and painful NPA have been the first-choice specimen for high-yield recovery of RSV by conventional methods. We wanted to find out whether the use of reverse transcription-polymerase chain reaction (RT-PCR) increases the usefulness of nasal swabs by comparing the performance of nasal swab-RT-PCR with NPA-immunoassays in the detection of RSV infections in children.

            • diagnosis
            • nasal swab
            • nucleic acid testing
            • respiratory syncytial virus
            • reverse-transcription polymerase chain reaction

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