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Potential effect of NICE tuberculosis guidelines on paediatric tuberculosis screening
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  • Published on: 22 March 2016
    Let's not jump the gun!

    We welcome the publication of further data regarding the performance of interferon-gamma-release assays (IGRA) in children. Taylor et al conclude from their data that 85% of chemoprophylactic treatment would have been saved by applying IGRA for the diagnosis of latent TB, as recommended by the NICE guidelines. This might sound very attractive to PCTs. However, they also point out the potential for missing cases of active...

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    Conflict of Interest:
    None declared.
  • Published on: 22 March 2016
    IGRA for children in the UK: patchy availability, problems with funding, unclarity about role.
    • Onajite M Etuwewe, Specialist Registrar, Paediatrics.
    • Other Contributors:
      • Andrew Riordan

    We were interested to read the study by Taylor of interferon gamma release assays (IGRA) in paediatric tuberculosis (TB) [1]. The authors highlight reliance on IGRA within NICE guidelines but advise caution when interpreting results.

    We surveyed paediatricians who manage TB in January 2008, asking about use of IGRA. Paediatricians were identified from a previous TB survey [2]. 39/100 paediatricians completed t...

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    Conflict of Interest:
    None declared.