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C-reactive protein is elevated in the offspring of parents with essential hypertension
  1. Juan Jose Diaz (jjdiaz{at}telecable.es)
  1. Hospital San Agustin. Pediatrics, Spain
    1. Juan Arguelles
    1. Functional Biology. University of Oviedo, Spain
      1. Ignacio Málaga
      1. Pediatric Nephrology. Hospital Universitario Central de Asturias. Oviedo, Spain
        1. Carmen Perillán
        1. Functional Biology. University of Oviedo, Spain
          1. Angeles Dieguez
          1. Inmunology. Hospital Universitario Central de Asturias. Oviedo, Spain
            1. Manuel Vijande
            1. Functional Biology. University of Oviedo, Spain
              1. Serafín Málaga (smalaga{at}hca.es)
              1. Pediatric Nephrology. Hospital Universitario Central de Asturias. Oviedo, Spain

                Abstract

                Background: Hypertension (HT) is a relevant risk factor for cardiovascular diseases (CVD). Studies in adults have shown that high sensitivity C-reactive protein (CRP) levels are associated with increased risk of CVD, including essential hypertension (EHT). Genetic influence is widely accepted as a risk factor for CVD. The aim of the present study was to analyze the association of high sensitivity CRP levels to other cardiovascular risk factors in children and young adults with at least one of their parents with EHT.

                Methods: Fifty-one healthy children and young adults (28 boys) with at least one hypertensive parent, collected prospectively from primary care centres and 69 (41 boys) whose parents were not hypertensive. High sensitivity CRP, fasting lipid profile, blood pressure (BP) and anthropometric variables were obtained for all participants.

                Results: CRP values were higher in the study group than in controls ( log CRP mean difference:-0.69; 95% confidence interval: -1.05 to -0.33), even when differences were adjusted by age, gender, body mass index (BMI),and trigliceride levels (P=0.01). No differences were observed in BP values between groups. In the study group 35.3 % of the participants had a CRP level ≥1 mg/L compared to a 14.5% in controls (P =0.009). CRP showed a significant correlation with body weight (rho=0.28, P=0.04), BMI (rho=0.32; P=0.02) and ponderosity index (rho=0.28; P<0.05).

                Conclusions: CRP is significantly higher in offspring from essential hypertensive parents. A significant positive relationship exists between BMI and serum CRP levels in this high risk group of children and young adults.

                • BMI
                • CRP
                • cardiovascular risk factors
                • hypertension
                • offspring

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