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O-124 Human Milk Cream Enhances Growth When Supplementing Standard Fortification Of An Exclusive Human Milk-based Diet In Vlbw Infants
  1. AB Hair1,
  2. CL Blanco2,
  3. KM Hawthorne1,
  4. AG Moreira2,
  5. ML Lee3,
  6. DJ Rechtman4,
  7. SA Abrams1
  1. 1Pediatrics, Baylor College of Medicine USDA/ARS Children’s Nutrition Research Center, Houston Texas, USA
  2. 2Pediatrics, University of Texas Health Science Center, San Antonio Texas, USA
  3. 3Research and Development, Prolacta Bioscience, Industry California, USA
  4. 4Medical Affairs, Prolacta Bioscience, Industry California, USA

Abstract

Background The use of an exclusively human milk (HM)-based diet lowers the incidence of NEC, however concerns exist regarding adequate growth. Frequently, donor and maternal HM have a low caloric content. A HM cream -derived supplement can increase the caloric density of an exclusive HM-based diet.

Objective Determine if premature infants fed an exclusive HM-based diet and a HM cream-derived supplement (Cream) would have equal growth compared to infants fed a standard feeding regimen (Control).

Methods In a prospective randomised study, infants with BW 750–1250 grams (g) were assigned to a dietary group. All infants received mother’s own milk or donor HM, with donor HM-derived fortifier. Cream group also received a HM-derived cream supplement if the HM tested < 20 kcal/oz (infrared HM analyzer). F/U continued until 36 weeks PMA. Primary outcomes included growth velocities and incidences of NEC and sepsis. Non-inferiority was established if the lower bound of weight velocity exceeded -3 g/kg/day.

Results There were no differences in demographics exceptrace (p = 0.02). Theone-sided 95% lower bound of the confidence interval for the difference in meanvelocity (cream-control) was 0.38 g/kg/day.

Abstract O-124 Table 1

Comparison of growth velocities

Conclusions Cream group infants had better weight and length velocity. HM cream-derived supplement should be considered as a supplement to an exclusive HM-based diet.

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