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PO-1002 The Significance Soluble Markers Of Activation And Apoptosis Of Immune Cells In Children With Atopic Bronchial Asthma
  1. V Bulgakova1,
  2. I Balabolkin2
  1. 1Department of Scientific Research, Scientific Centre of Children Health, Moscow, Russia
  2. 2Department of Pulmonology and Allergology, Scientific Centre of Children Health, Moscow, Russia

Abstract

Background In the pathogenesis of allergic diseases it is assumed the role of apoptotic mechanism of allergic inflammation and immunosuppression.

Objective To define clinical value of apoptosis markers of immunocompetent cells at children with atopic bronchial asthma (BA).

Materials and methods In blood serum of the 96 children in the age from 5 till 16 years (15 healthy and 81 with BA) by enzymeimmunoassay analysis of the use of commercial sets certain level of soluble membrane molecules, which are markers of modulation processes activation and apoptosis of immunocompetent cells: sCD30, sCD40, sCD95 (sApo-1/FAS), soluble FAS ligand (sFASL), ligand TRAIL (Apo2L), enzyme Caspase-1/ICE and protein Annexin V.

Results Authentic differences of concentration of the investigated indicators at children with BA from their referential levels (p).

Conclusion The level estimation soluble markers of activation and apoptosis immune cells can be used as additional diagnostic and prognostic criterion of weight and expressiveness of an atopic bronchial asthma at children.

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