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O-083a Coagulase-negative Staphylococcal Infections In Uk Neonatal Units (nnus)
  1. A Kent1,
  2. C Kortsalioudaki1,
  3. T Watts2,
  4. P Satodia3,
  5. N Kennea4,
  6. N Embleton5,
  7. P Clarke6,
  8. J Chang7,
  9. R Geethanath8,
  10. T Scorrer9,
  11. PT Heath1
  1. 1Paediatric Infectious Diseases Research Group Clinical Sciences, St George’s University of London, London, UK
  2. 2Neonatal Services, Evelina London Children’s Hospital Guy’s and St Thomas’ NHS Foundation Trust, London, UK
  3. 3Neonatal Services, University Hospital of Coventry and Warwickshire, Coventry, UK
  4. 4Neonatal Services, St George’s Healthcare Trust, London, UK
  5. 5Newcastle Neonatal Services, Royal Victoria Infirmary Newcastle Upon Tyne, Newcastle, UK
  6. 6Neonatal Services, Norfolk and Norwich University Hospital, Norwich, UK
  7. 7Neonatal Services, Croydon University Hospital, London, UK
  8. 8Neonatal Services, City Hospitals Sunderland (Sunderland Royal Hospital), Sunderland Tyne and Wear, UK
  9. 9Neonatal Services, Queen Alexandra Hospital, Portsmouth, UK

Abstract

Background and aims Advances in neonatal intensive care have resulted in improved survival and outcomes of increasingly preterm and very-low-birth-weight (VLBW) neonates. Invasive interventions contribute to higher rates of infections in these infants. This study aims to describe infections with coagulase-negative Staphylococci (CoNS) in UK NNUs participating in a neonatal infection surveillance network (neonIN).

Methods neonIN is a web-based surveillance system (www.neonin.org.uk). Details of CoNS cases between January 2010 and May 2014 were extracted. Episodes were considered clinically significant if the infant was treated with at least 5 days of appropriate antibiotics and CRP was >10 mg/L. Repeated growth within 10 days was considered the same episode.

Results 440 episodes met the study inclusion criteria (399 infants, 23 NNUs). Incidence was 7.7/1000 NNU-admissions. Baseline characteristics for these episodes are shown in table-1. Resistance data were available for 250/440 (56.8%) episodes with high rates of resistance to flucloxacillin 89.9% (169/188) and penicillin 94.4% (67/71) and moderate resistance to teicoplanin 20.3% (14/69). Susceptibility to vancomycin was high 98.3% (169/172).

Abstract O-083a Table 1

Median (IQR). LOS: late-onset sepsis, occurring after 48-hours of age. PNA: postnatal age. CRP: maximum CRP within 48 h ofthe positive culture. CVC: central-venous catheter. CVC removal: removal of the CVC due to the infection episode

Conclusions To our knowledge, this is the largest reported cohort of neonatal CoNS infections. Most babies were <34 weeks gestation and <2000 g birth-weight and had a CVC in-situ which was removed in around half of episodes. Prevention, as well as improved strategies for identifying significant CoNS infections should be prioritised.

On behalf of the Neonaotal Infectiion Surveillance Network (neonlN).

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