Background Cerebral palsy (CP) is common cause of disability in children. The aetiology of cerebral injury in CP is multifactorial, and recent studies suggested that genetic factor maybe contributed to the development of CP. Polymorphism C677T MTHFR gene influenced homocysteine metabolism that has neurotoxic effect.
Aim This is a preliminary study. The aim of this study was to evaluate the correlation between polymorphism C677T MTHFR gene and homocysteine level in CP children in Bandung, Indonesia.
Methods This is the cross sectional study. The CP children, 4–14 years old were analysed C677T polymorphism in the MTHFR gene and homocysteine level. The data of this study were analysed with SPSS program, t-tests were used, and statistical significance was defined as p value ≤ 0,05.
Results Thirty six spastic CP children, GMFCS I-III (22 males and 14 females; mean age 9,8 years) from school for disability children at Cibiru and Suryakanti (centre for children with special needs) in Bandung, Indonesia. There is a heterozigote polymorphism C677T MTHFR gene in 7 children (5 males and 2 females). The mean of homocysteine level is 8,69. We found no significant correlation between polymorphism C677T MTHFR gene and homocysteine level in CP children (p = 0,89)
Conclusion Preliminary data shows no correlation between polymorphism C677T MTHFR gene and homocysteine level in CP children in Bandung, Indonesia. However more subjects are required to further studies.
- cerebral palsy
- MTHFR gene
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