Article Text


PO-0794 New Tubular Injury Markers In Children With Solitary Functioning Kidney
  1. K Taranta-Janusz,
  2. A Wasilewska,
  3. M Dmochowska,
  4. M Pszczólkowska,
  5. L Janusz
  1. Deapartment of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland


The present study aimed to assess whether urinary profiles of the following lysosomal exoglycosidases: N-acethyl-β-hexosaminidase (HEX), its isoenzymes A (HEX A) and B (HEX B), α – fucosidase (FUC), β -galactosidase (GAL), α – mannosidase (MAN), and β – glucuronidase (GLU) are useful biomarkers of tubular dysfunction in children with solitary functioning kidney (SFK).

Methods We measured HEX, its isoenzymes HEX A, HEX B and FUC, GAL, MAN, GLU urinary activity in 52 patients with SFK. Patients were subdivided in two groups: congenital SFK (cSFK) - unilateral renal agenesis and acquired SFK (aSFK) - unilateral nephrectomy. The reference group (RG) contained 60 healthy children sex and age matched.

Results Urinary activity of all exoglycosidases in SFK was significantly higher than in RG (p < 0.05). There was no difference in exoglycosidases activity between cSFK and aSFK (p > 0.05). HEX, its isoenzymes HEX A, HEX B negatively correlated with eGFR, and all estimated parameters correlated positively with albumin/ creatinine ratio (p < 0.001).

Conclusion Urinary activity of HEX, its isoenzymes HEX A, HEX B, FUC, GAL, MAN, and GLU is elevated in children with SFK. Long-term follow-up studies in larger groups of children with SFK may help us better understand their clinical significance.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.