Introduction and aim Surfactant replacement is a corner stone therapy for respiratory distress syndrome (RDS) and has been shown to be both safe and efficacious for premature infants. The aim of this study was to assess the immediate changes in lung mechanics caused by administration of two different natural surfactants. Secondary aim of this study was to determine the relationship between initial lung mechanics and occurrence of bronchopulmonary dysplasia (BPD).
Method Preterm infants who were
Results 10 premature infants were studied. Mean gestational age was 28.4 ± 1.6 (26–31) weeks and mean birth weight was 955 ± 155 (710–1250) g. Five infants received beractant and the other five received poractantalpha. The alteration of lung mechanics after surfactant administration was summarized in Table 1.
Conclusion Surfactant therapy significantly reduced the resistance and improved the lung compliance. These effects were not directly related to the type of surfactant administered.