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PO-0761 Clinical And Evolutive Peculiarities Of The Bronchopulmonary Dysplasia And Wilson-mikity Syndrome In Premature Children
  1. S Sciuca,
  2. R Eremciuc,
  3. L Pinzaru,
  4. D Rotaru,
  5. E Oineagra
  1. Department of Pediatrics, State University of Medicine and Pharmacy, Chisinau, Moldova

Abstract

Background Bronchopulmonary dysplasia (BPD) and Wilson-Mikity syndrom (WMS) are specific respiratory diseases in premature infants, and utilisation of advanced management techniques will increase the prognosis and life expectancy in children with BPD and WMS.

Aim To assess clinical features and impact of BPD and WMS on the appearance of chronic pulmonary diseases in premature children.

Methods The study pressents the results of a clinical and evolutive analysis of 10 children with BPD and 4 with WMS that were born premature with a brith weigth of 700–1400 g, gestational age 31.92 ± 2,28 weeks.

Results The comparative analysis showed clinical and explorative differences in children with BPD and those with WMS. Though the prematurity degree was similar, the onset of clinical signs in children with WMS was later comparing with those with BPD (9,5 ±2,37 vs 1,4 ± 0.14 days of life, p < 0.01). Respiratory symptoms in the first year of life were less persistent in children with WMS versus those with BPD, who still presented with suggestive imagistic sings (diffuse pulmonary nodular infiltrates accompanied by cystic changes and areas of hiperinflation). Pulmonary pathology progressed inchildren with BPD, causing death in 2 children at 3–5 months of life due to severe complication. In children with WMS, in evolution was favourable with fewer exacerbations, in 1 case with complete involution confirmed radiologically by the age of 1 year.

Conclusion BPD in premature children has high risks of progression into cronic pulmonary disease and death. In WMS the clinical signs appear later, are less severe and their evolution is more favourable.

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