Aim To investigate the endothelial dysfunction in term newborns with Intrauterine growth retardation (IUGR).

Methods For this purpose 30 term infants were examined and divided in two groups: control group included 15 healthy newborns, main group-15 infants with IUGR. In order to determine endothelial dysfunction sICAM-1 and sVCAM-1 was detected by Uscn (Life Science Inc., USA) kits in 1st-3rd and 5th-7th days. The Student t-test and the Mann-Whitney test were used for comparison of parametric and non-parametric parameters.

Results On the1st-3rd day the levels of the both adhesion molecules was higher in main group than the control group. The level of sVCAM in the main group increasing twice in the 5–7 th days became accurate (p?0,05). The level of sICAM-1 in the 5–7 days increased less than control group and was inaccurate by statistic.

Conclusion Growth of sVCAM-1 in the main group bowth in the 1–3rd days and 5–7 th days indicates ongoing influence of damaging factor. The less increase of sICAM-1 in the main group indicates the reduction of compensator mechanism of immun system in this children.