Aim To compare cord blood osteocalcin, leptin and TNF α levels in gestational diabetic and normal pregnancies.
Method 191 deliveries were included in this research. 41 (21.5%) of pregnancies were gestational diabetic and 159 (78.5%) of pregnancies were normal. Cord blood osteocalcin, leptin and TNF α levels were compared.
Results There was no significant difference among birth weights (p:0.409), heights (p:0.07), head circumferences (p 0.201), gender (p:0.4), gestational weeks (p:0.201), ponderal index (0.564) between groups. There was no significant difference between groups regarding pregnancy complications. However, hypothyroidism was more common in gestational diabetic group (p:< 0.001). In addition, hypoglycemia was more common in gestational diabetic group (p:0.047).
Gestational diabetic group’s cord blood osteocalcin levels were higher than in non diabetic group (p:0.037). Cord blood TNF α (p:0.813) and leptin average levels (p: 0,212) were not statistically different. Osteocalcin, leptin and TNF α levels were not statistically different between boys and girls.
Discussion Osteocalcin; originating from bones, increases insulin sensitivity in peripheral organs and insulin secretion. Leptin is known to inhibit insulin and osteocalcin secretion. Osteocalcin level increase in gestational diabetic group, may be related to osteocalcin regulation of blood glucose levels. Cord blood leptin and TNF α levels showed no significant difference between groups, probably due to proper regulation of cord blood glucose levels during gestation.