Article Text


PO-0572 Umbilical Venous Catheters With Agion Antimicrobial System In A Dutch Nicu
  1. A van den Hoogen
  1. Neonatology, University Medical Center Utrecht, Utrecht, Netherlands


Background The majority of preterm infants at NICUs receives a central venous, or umbilical vein catheter (UVC) and is therefore at risk for catheter associated sepsis. Silver-impregnated UVCs with the AgIONTM antimicrobial system may prevent sepsis and may have longer insertion time.

Objective To assess sepsis and additional CVC insertion with the use of silver-impregnated UVCs compared with conventional ones.

Methods Catheter-duration, sepsis and additional CVC use was compared between infants with silver-impregnated UVCs (silvergroup) during 1 year (2012–2013) and infants with conventional UVCs (controls) during 2011, when inserted >3 days.

Results In 156/249 (2012–2013) infants a silver-impregnated and all 273 with an UVC in 2011 a conventional UVC was inserted. Mean catheter-duration was 5.8 (3–15) days in the silvergroup vs 5.7 (3–12) days in the controls (NS). 11/156 (7%) infants from the silvergroup developed sepsis during catheterisation vs 17/267 (6.4%) controls [NS]. Main causative microorganisms: CoNS (62.5%), S. aureus (15.6%), Enterobacter (9.3%). In 22/156 infants of the silvergroup, UVC use was longer than 8 days, vs in 20/273 controls (NS). 3/22 of the silvergroup with UVC use > 8 days developed sepsis vs 1/273 controls (p = 0.015). Significant more infants in the silvergroup needed additional CVC insertion 18/156 (11.5%) vs in 28/273 (10.3%) controls (p = 0.00).

Conclusions Duration of > 8 days of silver-impregnated UVC significantly increased the risk for sepsis as compared with conventional UVC use.

Silver-impregnated UVCs were not inserted for longer periods than conventional UVCs.

Anti-infectious advantage of the silver-impregnated UVCs could not be proven.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.