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O-052 25-hydroxy Vit D, Adiponectin Levels And Cardiometabolic Risk Factors In A Sample Of Obese Children
  1. S El-Masry1,
  2. NE Hassan1,
  3. RA El Banna1,
  4. ER Abdel-Hamid2,
  5. M Al-Tohamy1
  1. 1Biological Anthropology, National Research Centre, Giza, Egypt
  2. 2Child Health, National Research Centre, Giza, Egypt

Abstract

Association between vitamin D, adiponectin and obesity is a matter of debate, as they play important role in linking obesity with different cardiometabolic risk factors.

Objectives Evaluation of the association between metabolic risk factors with both adiponectin and vitamin D levels and that between adiponectin and vitamin D among obese Egyptian children.

Subjects and methods This case-control cross sectional study consisted of 65 obese and 30 healthy children, aged 8–11 years. 25-Hydroxy vitamin D [25(OH) D] level, serum adiponectin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were measured.

Results The mean 25(OH) D levels in the obese and control groups were 29.9 ± 10.3 and 39.7 ± 12.7 ng/mL respectively (?? < 0.001). The mean 25(OH) D and adiponectin levels in the obese were lower than that in the control group (?? < 0.0001). 25(OH)D were inversely correlated with body mass index (BMI), triglyceride, total cholesterol and LDL-cholesterol (LDL-C), While adiponectin level were inversely correlated with systolic blood pressure (SBP), and diastolic blood pressure (DBP), and positively correlated with HDL-C However, there is no relation between 25(OH) D and adiponectin levels among obese children and total sample.

Conclusion Inspite of strong association between vitamin D and adiponectin levels with metabolic risk factors and obesity, there is no relation between 25(OH) D and adiponectin levels. In obese children, there are significant negative correlations between 25(OH) D with lipid profile, and between adiponectin levels with blood pressure. At certain adiponectin level, the relation between it and BMI disappears.

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