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Metabolism
O-051 Impaired Endothelial Function In Adolescents With Type 1 Diabetes Or Overweight, Measured By Peripheral Artery Tonometry
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  1. A Pareyn1,
  2. K Casteels2,
  3. K Allegaert3,
  4. W Asscherickx1,
  5. E Peirsman4,
  6. P Verhamme5,
  7. J Vinckx1
  1. 1Department of Pediatrics, University of Leuven, Leuven, Belgium
  2. 2Department of Pediatrics Department of Development and Regeneration, University of Leuven, Leuven, Belgium
  3. 3Neonatal Intensive Care Unit Department of Development and Regeneration Department of Pediatrics Department of Development and Regeneration, University of Leuven, Leuven, Belgium
  4. 4Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium
  5. 5Vascular Medicine and Haemostasis, University of Leuven, Leuven, Belgium

Abstract

Background and aims Reactive hyperemia-peripheral artery tonometry (RH–PAT) is a non-invasive method for endothelial function assessment. The goal of this study is to investigate endothelial function as assessed with the RH-PAT in control adolescents and adolescents with type 1 diabetes (T1D) or overweight.

Methods RH-PAT score and baseline pulse amplitude was measured after an overnight fast in 25 control subjects (age 12–20 years), 34 adolescents with T1D and 27 adolescents with overweight or obesity.

Results RH-PAT score was lower in adolescents with T1D compared to healthy controls (1.6 [1.3–2.0] versus 1.9 [1.7–2.4], p = 0.0154). The same trend was seen in adolescents with overweight or obesity (1.5 [1.3–2.0] versus 1.9 [1.7–2.4], p = 0.027). Similarly, the baseline pulse amplitude was higher in the group of patients with T1D (373.0 [208.3–522.0] versus 145.3 [52.3–300.2], p = 0.0033) and in adolescents with overweight or obesity compared to healthy controls (416.3 [360.3–675.7] versus 145.3 [52.3­300.2], p < 0.0001). Within the group with overweight, a significantly positive correlation was seen between baseline pulse amplitude and body mass index (BMI) standard deviation score (SDS) (r = 0.39 [0.006–0.67], p = 0.047).

Conclusions Endothelial dysfunction, quantified by lower RH-PAT score or higher baseline pulse amplitude, was observed in both adolescents with T1D and with overweight. Early detection of vascular changes in these high-risk patient groups may allow targeted interventions to reduce cardiovascular disease in adulthood.

https://doi.org/10.1136/archdischild-2014-307384.119

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