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PO-0401 Il-6 Polymorphism At Position-174 In Newborn Infants With Perinatal Arterial Ischaemic Stroke: Association With Adverse Outcome
  1. JC Harteman1,
  2. HLDM Willemen2,
  3. CJ Heynen2,
  4. A Huisman3,
  5. LJ Bont4,
  6. F van Bel1,
  7. MJNL Benders1,
  8. LS de Vries1,
  9. F Groenendaal1
  1. 1Neonatology, Wilhelmina Children’s Hospital, Utrecht, Netherlands
  2. 2Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, Netherlands
  3. 3Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, Netherlands
  4. 4Paediatric Infectious Disease, Wilhelmina Children’s Hospital, Utrecht, Netherlands

Abstract

Background Inflammation has been proposed as a hallmark in the pathophysiology of stroke. A functional polymorphism in the interleukin (IL)-6 gene at position-174, encoding for the pro-inflammatory cytokine IL-6, is associated with an increased risk of neonatal brain injury or development of cerebral palsy. The aim was to study whether the IL-6-174 G/C polymorphism increased the risk of perinatal arterial ischaemic stroke (PAIS) or subsequent adverse sequelae.

Methods Infants born at or above 37 weeks gestation with PAIS diagnosed by neonatal MRI (n = 63) were included. Genotyping of the IL-6-174 G/C polymorphism was performed and compared to 1008 random population controls. Perinatal variables of case infants were reviewed.

Results There were no differences in IL-6-174 genotype between infants with PAIS and population controls. In a multivariable analysis, independent risk factors for adverse outcome after PAIS in a middle cerebral artery territory included CG genotype (OR 5.9; 95% CI 1.02–33.9) and male sex (OR 4.2; 95% CI 1.04–17.2).

Conclusion The distribution of the IL-6-174 C >G promotor polymorphism did not differ between infants with PAIS and population controls and therefore do not seem to play a role in stroke risk. However, the IL-6-174 GC genotype was more common among infants who had an adverse outcome following PAIS in the middle cerebral artery territory, suggesting that the level of inflammation does play a role in outcome after PAIS. This may be relevant for neuroprotective strategies.

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