Article Text

PDF

PO-0365 Histological Aspects Of The Feto-placental Interface In The Gestational Diabetes Mellitus
  1. R Ilie1,
  2. C Ilie2,
  3. F Capitan2,
  4. A Nyiredi2,
  5. I Enatescu2
  1. 1Pathology, Emergency Children’s Hospital Louis Turcanu, Timisoara, Romania
  2. 2Neonatology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania

Abstract

Background and aims We studied the feto-placental interface, in the Gestational diabetes mellitus (GDM), to present his specific structural modifications and his cellular injuries.

Method An optical microscopic analysis was performed on 30 placentas, obtained after delivery for two equal groups representing mothers with GDM and normal pregnancies. The samples obtained by sections were specifically prepared for the study using three types of histological stains. The histological observation centred upon the: trophoblast, villous stroma and fetal capillary. The statistical study of the data was performed using SPSS 17.0.

Results Through optical microscopy were identified varying degrees of lesions consisting of: villous oedema, proliferation and villous fibrosis of the capillaries, large number of syncytial knots, important fibrinoid necrosis, moderate fibrin thrombi, hyperplasia of the syncytiotrophoblast, chorangiosis, slightly thickened of the basement membrane of the feto-maternal interface.

Conclusion Histological changes in the placentas of women with GDM are significant factors contributing to fetal anoxia with impact on placental vascular permeability. A diabetic milieu causes vascular dysfunction, increasing angiogenesis in GDM is considerred to be the cause of the placental abnormalities and complications (miscarriage, stillbirth, macrosomia, and congenital anomalies).

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.