Article Text

PDF

PO-0185 Acute Respiratory Tract Infections (arti) In Hospitalised Children: Viruses, Interferon-alpha And Gamma, S-iga Levels
  1. A Goryaynova1,
  2. I Zakharova1,
  3. L Torshkoeva1,
  4. H Kurbanova1,
  5. N Koroid2,
  6. I Lagadze1
  1. 1Pediatrics, Russian Medical Academy of Postgraduate Education, Moscow, Russia
  2. 2Pediatrics, Tushino Children’s Hospital, Moscow, Russia

Abstract

Background Detection of respiratory viruses, IFN-alpha, gamma, s-IgA levels in the first 3 years old hospitalised children within 3 days of symptom onset.

Methods The human viruses were detected in nasal wash specimens obtained from 86 children by polymerase chain reaction (PCR), IFN-alpha, gamma, s-IgA plasma and nasal wash specimens levels, IFN-alpha, gamma induced production in vitro were investigated. The IFN-alpha production was induced by Newcastle disease virus, IFN-gamma production was induced by phytohemagglutinin.

Results Influenza virus B was detected in 35% investigations, A(H1N1) - 23%, A(H3N2) - 4%, Parainfluenza virus (PIV) - 5%, rhinoviruses (HRV) - 4%, metapneumovirus (HMPV) - 6%, bocavirus (HBoV) - 5%, Adenovirus (AdV) and Respiratory syncytial virus (RSV) - 9%. Seasonal features were found: A(H1N1) dominated in March (66.7%), B - in June (77,8%), PIV was recorded in March only. HRV and RSV were noted as the longest circulation (from January to May), AdV, HBoV, HMPV were detected from March to June. The s-IgA decrease less than 1.5 mg/ml was found in 75.8% children in nasal wash specimens. Serum IFN-alpha, gamma were decreasing below a sensitivity threshold (less 2 pg/ml) in 67.7% and 69.4%, especially in influenza children and in ARTI complications. The nasal wash specimens INF-alpha, gamma levels less than 2 pg/ml were found in 38.7% and 48.4%. The IFN-alpha, gamma induced levels in vitro were lowered in 22.6% and 40.3%.

Conclusions Our data demonstrate the IFN-alpha, gamma deficit in children with ARTI. It contributes IFN-alpha, gamma replaceable therapy in infants especially. This is very necessary the ARTI seasonal prevention.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.