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PO-0173 Peculiarities Of Interferon Status In Newborn Babies With The Human Herpesvirus 6 Infection
  1. LV Kravchenko1,
  2. AA Afonin1,
  3. MV Demidova1,
  4. MA Levkovich2,
  5. LM Zaurova1
  1. 1Pediatric Department, Rostov Scientific-Research Institute of Obstetrics and Pediatrics, Rostov-on-Don, Russia
  2. 2Department of Medical-Biological Problems, Rostov Scientific-Research Institute of Obstetrics and Pediatrics, Rostov-on-Don, Russia

Abstract

Background Diseases caused by viruses of Herpesviridae family belong to socially significant ones due to the diversity of their clinical manifestations, including even lethal outcomes. One of the most important mechanisms, by means of which immunocompetent cells participate in the defense against the herpetic infection, is connected with the production of immunoregulatory cytokines, particularly interferons α and γ (IFN-α and IFN- γ).

Aim To estimate the content of IFN-α and IFN- γ in newborn babies with the infection caused by human herpesvirus 6 (HHV-6).

Methods We examined 36 newborn babies with HHV-6 infection. Our control group consisted of 34 healthy for our purpose newborn babies without human herpesvirus infection. The level of interferon-α (IFN-α) and interferon-γ (IFN-γ) in the blood serum was determined by means of the reagent kit for the enzyme-linked immunosorbent assay ProCon IF2 Plus, ProCon If Gamma (Protein Contour LLC, Saint-Petersburg, Russia).

Results In the newborns with the human herpesvirus 6 infection there was a significant increase of the level of IFN-γ in the blood serum [1.28 (1.11–1.75) pg/ml] as compared to the control group [0.965(0.7225–1.125) pg/ml] (p

Conclusions The increase of IFN-γ level in the blood serum in the newborn babies with the human herpesvirus 6 infection is a reflection of antenatal antigen stimulation and indicates the timely start of IFN-γ participation in the process of antiviral defense. The absence of changes in IFN-α level indicates that it performs rather physiological than protective function.

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