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PO-0027 Interstitial Fluid Colloid Osmotic Pressure In Healthy Children
  1. HJ Guthe1,
  2. M Indrebø2,
  3. T Nedrebø3,
  4. G Norgård4,
  5. HJ Wiig3,
  6. A Berg1
  1. 1Department of Paediatrics, University of Bergen, Bergen, Norway
  2. 2Department of Clinical Medicine Faculty of Medicine, University of Oslo, Oslo, Norway
  3. 3Department of Biomedicine, University of Bergen, Bergen, Norway
  4. 4Department of Clinical Medicine Faculty of Medicine Section for Paediatric Heart- Lung- and Allergic Diseases, University of Oslo, Oslo, Norway

Abstract

Background and aims Colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange were small pressure alterations may result in fluid shifts into or out of the capillaries optimising homeostasis. This study was conducted to determine reference values of COP in healthy children, and to evaluate the methodology of harvesting interstitial fluid.

Methods COP in plasma and interstitial fluid isolated from nylon wicks implanted subcutaneously was measured in 99 healthy children from 2 to 10 years of age. Patients were sedated and intubated during wick implantation in arm and leg, and COP was analysed in a colloid osmometer.

Results Mean plasma COP in all children was 25.6 ± 3.3 mmHg. Arbitrary division of children in age groups, showed no significant difference in plasma or interstitial fluid COP values for patients less than 8 years, whereas patients of 8–10 years had significant higher COP both in plasma and interstitial fluid. There was no gender difference or correlation between COP in interstitial fluid sampled from arm and leg and no significant effect on interstitial COP of gravity. Prolonged implantation time did not affect interstitial COP.

Abstract PO-0027 Figure 1

Colloid osmotic pressure in plasma and interstitium. Colloid osmotic pressure in plasma (p) and interstitium (i) (arm and leg merged) related to age. There was significant difference in pressure beween 2–3 years and 8–10 years for plasma (p < 0.05, *) and between first three age groups and 8–10 years (p < 0.01, **) in interstitial fluid

Abstract PO-0027 Figure 2

Colloid osmotic pressure in arm and leg. Colloid osmotic pressure from wicks after implantation in arm vs. leg related to age. There was no significant difference in the pressures obtained in arm and leg

Conclusions This study justifies the presumption that plasma and interstitial COP in healthy children are similar to adults. Children between 8 and 10 years had higher values than younger age groups. Knowledge of interaction between colloid osmotic forces in health and disease can be helpful in diseases associated with fluid imbalance and may be crucial in deciding different fluid treatment options.

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