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O-006 Follow – Up Outcomes From The Boost-ii Uk Trial Of Oxygen Saturation Targeting In Preterm Infants
  1. B Stenson,
  2. P Brocklehurst,
  3. P Cairns,
  4. S Deshpande,
  5. BW Fleck,
  6. HL Halliday,
  7. E Juszczak,
  8. A King,
  9. N Marlow,
  10. W Tin,
  11. S Wardle
  1. BOOST II UK Collaborative Group, National Perinatal Epidemiology Unit, Oxford, UK

Abstract

Background and aims The optimal target range for pulse oximeter saturation (SpO2) in extremely preterm infants is unknown. BOOST-II UK is one of 5 international studies that have recently investigated this.

Methods Preterm infants born before 28 weeks’ gestation were randomised within 24 h of birth to an SpO2 target range of 85–89% or 91–95%. The intervention used masked offset oximeters and was continued until 36 weeks’ gestation. The primary outcome was a composite of death or serious neurosensory disability (SND) in survivors at age 2 corrected for prematurity, evaluated in 745 infants cared for using updated trial oximeters. A sensitivity analysis restricted to infants assessed by a Bayley III examination and a secondary analysis including a further 228 infants who were studied before the oximeters were updated were also performed.

Results The primary outcome was determined for 722 (96.9%) of infants.

Abstract O-006 Table 1

The sensitivity analysis showed similar results. In the secondary analysis the mortality difference was 4.9% (p = 0.05). Severe visual loss did not differ between groups.

Conclusions The higher SpO2 target group had 8.5% greater survival with no increase in serious neurosensory disability. For infants born before 28 weeks’’ gestation, SpO2 targets below 90% are not recommended.

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