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PS-319 Cord Blood Vitamin D Status And Newborn Body Composition
  1. E Malchau Carlsen1,
  2. KM Renault2,
  3. V DeKnegt3,
  4. K Nørgaard4,
  5. D Cortes3,
  6. KF Michaelsen5,
  7. C Mølgaard5,
  8. O Pryds6
  1. 1Department of Pediatrics, Hvidovre UniversityHospital University of Copenhagen, Hvidovre, Denmark
  2. 2Department of of Obstetrics and Gynaecology, Odense University Hospital University of Southern Denmark, Odense, Denmark
  3. 3Department of Pediatrics, Hvidovre University Hospital University of Copenhagen, Hvidovre, Denmark
  4. 4Department of Endocrinology, Hvidovre University Hospital University of Copenhagen, Hvidovre, Denmark
  5. 5Department of Sports Excercise and Nutrition, University of Copenhagen, Copenhagen, Denmark
  6. 6Department of Sports Excercise and Nutrition, Hvidovre University University of Copenhagen, Hvidovre, Denmark

Abstract

Background and aims Previous studies in newborns have found a positive association between adiposity and maternal and cord blood 25-hydroxy-vitamin D status (vit-D). It has been hypothesised that vit-D play a role in adipocyte metabolism and that this can be linked to obesity. Cord blood vit-D is closely associated with maternal vit-D concentration and is further affected by maternal obesity. The aim with our study was to examine the association between newborn cord blood vit-D and body composition where analyses were stratified by maternal pre-pregnancy obesity since this is a strong determinant of newborn body composition.

Methods Pre-pregnancy obese and normal weight mothers were included. Cord blood was collected at birth and newborn body composition was assessed using dual-energy X-ray absorptiometry within 48 h of birth. Sufficient cord blood and scans were obtained in 173(55%) mother-newborn dyads. Multiple linear regressions with vit-D was as a dependent variable were performed.

Results We included 41 pre-pregnancy normal weight-newborn dyads and 132 pre-pregnancy obese–newborn dyads. There was no difference in mean cord blood vit-D between offspring of normal weight and obese mothers (59.6 vs. 62.4 nmol/l (p = 0.64)). Vit-D was significantly associated with normal weight offspring body composition, positively with lean mass (p = 0.031) and inversely with fat% (p = 0.037) but was not associated with obese offspring body composition. See Table 1.

Conclusion We found an association between vit-D and newborn body composition in normal weight offspring. This implies that the effect of vit-D on newborn body composition may be determined by maternal weight.

Abstract PS-319 Table 1

Association between newborn cord blood vitamin D (nmol/l) and maternal age and parity and newborn body composition in normal weight and obese mothers offspring

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