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PS-286 Surfactant (s) Supplemented With Budesonide (b) For Prevention Of Bronchopulmonary Dysplasia – Biophysical And Chemical Stability Of S/b Mixture
  1. CM Chen1,
  2. LT Huang2,
  3. MH Wang3,
  4. TF Yeh4
  1. 1Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan
  2. 2Department of Pediatrics, Wan-Fang Hospital, Taipei, Taiwan
  3. 3Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan
  4. 4Maternal Child Health Research Center, Taipei Medical University, Taipei, Taiwan

Abstract

Background and aims Intra-tracheal instillation of budesonide (B) using surfactant (S) as a vehicle significantly improved pulmonary status. The stability of the S/B mixture has not been studied. The aim of study is to investigate if S can be used as an vehicle to facilitate B delivery in rats and if the S/B mixture is biophysically and chemically stable.

Methods and materials A Nano/PET digital scan was performed on rat that was intratracheally injected with S/18-F labelled B mixture, with 18-F-B only, or with free 18-F. The 18-F radioactivity was measured at 30 min. after injection. To test biophysical property, the dynamic surface tension behaviour of S/B suspension was conducted in Surfactometer. HPLC was performed with various S/B concentration ratios within 24 hrs after S/B mixing.

Results 1) 18-F-B radioactivity was detected more in the peripheral lung in rat supplemented with S than in rat without S. 2) using a concentration of S/B ≥ 50:1, the dynamic surface activity of S was minimally affected 3) HPLC analysis revealed no new compound detected within 24 h after mixing of S/B

Abstract PS-286 Table 1

Conclusions S can be used as an effective vehicle and that, with a S/B ratio of ≥ 50, the mixture is biophysically and chemical stable.

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