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PS-268 Stool Characteristics And Gastrointestinal Tolerance Of Chinese Infants Fed Term Formula Containing Increased Sn-2 Palmitate And Oligofructose: An Observational Study
  1. K Yerger1,
  2. M Mao2,
  3. J Ge3,
  4. R Northington1,
  5. M Yao1,
  6. J Nowacki1,
  7. N Hays1
  1. 1Clinical Science, Nestlé Nutrition, King of Prussia PA, USA
  2. 2Children’s Healthcare Department, Chengdu Women’s and Children’s Central Hospital, Chengdu, China
  3. 3Medical Department, Wyeth Nutritional (China) Company Ltd., Shanghai, China

Abstract

Background and aims Formula containing increased sn-2 palmitate with oligofructose (sn-2+OF) may improve stool consistency. We hypothesised that hard and watery stool incidence among infants fed α-lactalbumin-enriched formula with sn-2+OF would be ≤2.5% (upper limit of 80% CI < 5.0%).

Methods Healthy term infants (n = 440) aged ~42 days were enrolled in this 48-day study on their current feeding regimens: formula-fed (n = 142), HM-fed (n = 143), or mixed-fed (n = 155). Stool consistency was assessed at 4 visits using a 3-day diary with validated 5-point scale (1 = watery, 5 = hard). Gastrointestinal (GI) tolerance was assessed using a validated questionnaire (score range = 13–65; lower values indicate better tolerance).

Results Incidence of hard stools across visits ranged from 0.7% [80% CI: 0.1–2.7] to 2.1% [0.8–4.6] for formula-fed infants, with incidence rates ≤0.8% in mixed-fed, and no hard stools reported in HM-fed groups. Incidence of watery stools ranged from 2.8% [1.2–5.4] to 5.0% [2.8–8.3] for formula-fed infants, which was lower than the incidence rates for mixed-fed (≤8.2%) and HM-fed (≤16.3%) groups. Stool consistency score (2 = runny, 3 = mushy soft) of formula-fed infants (2.9) was higher than HM-fed infants (2.4–2.5; p

Conclusions Formula with sn-2+OF fed to Chinese infants results in soft stools and low incidence of hard and watery stools. Low GI tolerance scores indicate the formula is well tolerated.

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