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PS-244a Is Vitamin D Deficiency A Risk Factor For Urinary Tract Infection In Children?
  1. M Tekin1,
  2. C Konca1,
  3. V Celik1,
  4. H Almis1,
  5. Z Kahramaner2,
  6. A Erdemir2,
  7. A Gulyuz3,
  8. F Uckardes4,
  9. M Turgut1
  1. 1Pediatrics, Adiyaman University School of Medicine, Adiyaman, Turkey
  2. 2Pediatrics Neonatology Clinic, Adiyaman University School of Medicine, Adiyaman, Turkey
  3. 3Pediatrics, Sevgi Hospital, Malatya, Turkey
  4. 4Statistics, Adiyaman University School of Medicine, Adiyaman, Turkey

Abstract

Background and aims There is increasing evidence that vitamin D deficiency plays an important role in susceptibility to infections. We aimed to examine whether there is any association between serum levels of 25-hydroxy vitamin D (25(OH)D3) and urinary tract infections (UTI) among children.

Methods Serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH) and serum 25(OH)D3 levels were measured in 82 children aged 2 months to 12 years with first episode of UTI, not having any risk factor for UTI, and 64 healthy control children. The age, gender, weight, height, fever, vitamin D or calcium supplementation, urinalysis and urine culture were recorded.

Results The serum levels of 25(OH)D3 were significantly lower in the study group compared to healthy control group (11.69 ± 3.25 ng/mL vs. 27.57 ± 4.72 ng/mL; p < 0.001). There was statistically significant difference in serum 25(OH)D3 levels between the patients with upper UTI compared to the patients with lower UTI (8.63 ± 2.76 ng/mL vs. 14.22 ± 2.97 ng/mL; p < 0.001). The serum levels of 25(OH)D3 were significantly lower in girls compared to the boys in the study group (10.91 ± 3.42 ng/mL vs. 13.20 ± 4.38 ng/mL; p < 0.001). Multivariate analysis showed that a serum 25(OH)D3 level of < 15 ng/mL (odds ratio 3.50, 95% confidence interval 1.62–7.57; p = 0.001) was associated with UTI in children.

Conclusions Our results suggest that vitamin D deficiency is a risk factor for UTI in children and low serum level of vitamin D in girls is one of the reason for prone to UTI.

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