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PS-243 The Clinical Significance Of Urinary Neutrophil Gelatinase Associated Lipocalin, Kidney Injury Molecular-1 And Interleukin-18 In Acute Kidney Injury After Childhood Rdiopulmonary Bypass
  1. HJ Liu1,
  2. YL Shen1,
  3. L Sun1,
  4. XY Kuang1,
  5. RF Zhang2,
  6. H Zhang3,
  7. XB Li2,
  8. WY Huang1
  1. 1Nephrology and Rheumatology, Shanghai Children’s Hospital Shanghai Jiaotong University, Shanghai, China
  2. 2Cardiothoracic Surgery, Shanghai Children’s Hospital Shanghai Jiaotong University, Shanghai, China
  3. 3Clinical Laboratories, Shanghai Children’s Hospital Shanghai Jiaotong University, Shanghai, China

Abstract

Background and aims To investigate the value of urinary neutrophil gelatinase associated lipocalin (NGAL) kidney injury molecular-1 (KIM-1) and interleukin-18 (IL-18) in the diagnosis of acute kidney injury (AKI) following childhood cardiopulmonary bypass (CPB).

Methods 67 patients accepted CPB assigned to acute kidney injury group (group AKI) ornon-acute kidney injury group (group non-AKI). Samples were taken regularly after CPB 30 min, 2 h, 4 h, 24 h, 48 h and 72 h.

Results The incidence of AKI was 34%, including 15 cases with Risk stage AKI, 4 cases with Injury stage AKI, 3 cases with Failure stage AKI, 1 cases with Loss stage AKI. Comparing with the non-AKI group, the levels of urinary NGAL/Cr was much higher than that of controls after CPB 24 h. The levels of urinary NGAL/Cr were higher than that of controls after CPB 48 h. The values for the AUC were determined for urine KIM-1 as 0.698 and 0.662 after CPB 24 h and 48 h. Comparing with the pre-operation, the levels of urinary IL-18/Cr were higher than that of controls after CPB 30 min. AKI group has a higher level than that of non-AKI group after CPB 4 h.

Conclusion In this study, our results identify that possibly urine NGAL, KIM-1 and IL-18 are more significative than Scr for early detection. However, the exact clinical value needs to be further elucidated.

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