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PS-236 Advanced Glycation End Products And Cardiovascular And Renal Parameters In Children With Chronic Kidney Disease
  1. S Gréteau1,
  2. A Doyon2,
  3. B Llanas3,
  4. P Barat3,
  5. J Harambat3
  1. 1Pédiatrie, Centre Hospitalier de Pau, PAU, France
  2. 2Pédiatrie, Université d’Heidelberg, Heidelberg, Germany
  3. 3Endocrinologie et Néphrologie Pédiatrique, Centre Hospitalier Universitaire, Bordeaux, France

Abstract

Introduction Advanced glycation end products (AGE) are increased in many tissues during ageing. AGE are involved in cellular and endothelial damage in diabetes, chronic kidney disease (CKD) and cardiovascular disease. Increased levels, measured by skin autofluorescence (AF), are associated with the risk of cardiovascular events in adult patients with end- stage CKD. A high level of AF is a marker of progression of chronic kidney disease in adults with CKD at stage 3. We estimated the accumulation of tissue AGEs and looked for correlations of skin AF with markers of cardiovascular risk and progression of renal disease in children with CKD over a 2 years period.

Methods A cross-sectional pilot study compared 14 children with stage 3–5 CKD with a control group of children with the same age. We analysed associations between skin AF and markers of cardiovascular function, and with the progression of CKD.

Results The skin AF values were significantly higher (p < 0.01) in CKD children than in controls. In CKD children, skin AF was significantly associated with intima-media thickness of the common carotid artery (p = 0.01) and showed a trend with ambulatory blood pressure over 24 h (p = 0.06). Finally, skin AF was associated with changes in the glomerular filtration rate after 2 years of follow-up (p = 0.03).

Conclusion Noninvasive measurement of tissue accumulation of AGE by skin AF could be, in a near future, a useful tool in the assessment of cardiovascular risk and progression of chronic kidney disease in children with renal impairment.

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