Background and aims To investigate the new biomarkers of acute kidney injury, as well as to conform the values of response gene to complement-32 (RGC-32) protein for early diagnosis of acute kidney injury in children who had undergone cardiopulmonary bypass (CPB).
Methods 67 patients accepted CPB assigned to acute kidneyinjury group (AKI group) or non-acute kidney injury group (non-AKI group). Serum samples were taken regularly after CPB 30 min, 2 h, 4 h, 24 h, 48 h and 72 h for serumRGC-32, creatinine (Scr) and Cystatin C (CysC) measurement.
Results The incidence of AKI was 34%, including 15 cases with Risk stage AKI, 4 cases with Injury stage AKI, 3 cases with Failure stage AKI, 1 cases with Loss stage AKI. The values for sensitivity of serum RGC-32 after CPB 30 min, 2 h and 4 h as 0.914, 0.824, 0.824 and the values for specificity of serum RGC-32 as 0.619, 0.667, 0.810, respectively.
Conclusion In this study, our results first identify that possibly the sensitivity of serum RGC-32 for detecting AKI are much higher than that of Scr and serum CysC in children who had accepted CPB, and that RGC-32 may be a new biomarker for early detection of AKI. However, the conclusion needs to be further elucidated.