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PS-207 Plasma Pro-endothelin-1 As Marker Of Bronchopulmonary Dysplasia
  1. S Wellmann1,
  2. I Pramana1,
  3. B Grass2,
  4. K Spanaus3,
  5. S Fouzas4,
  6. C Bührer5,
  7. P Baumann6
  1. 1Neonatology, University Children’s Hospital Both Basel, Basel, Switzerland
  2. 2Intensive Care Medicine and Neonatology, University Children’s Hospital Zurich, Zurich, Switzerland
  3. 3Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
  4. 4Neonatology, University Hospital of Patras, Patras, Greece
  5. 5Neonatology, Charité University Medical Center, Berlin, Germany
  6. 6Neonatology, University Hospital Zurich, Zurich, Switzerland

Abstract

Background Endothelin-1 (ET-1) is a potent pulmonary vasoconstrictor, involved in lung injury and remodelling. ET-1 can be estimated by measuring its stable by-product, C-terminal pro-ET-1 (CT-proET-1), in plasma.

Aims To investigate CT-proET-1 values in very preterm infants (gestational age <32 weeks) from birth to postmenstrual age (PMA) of 36 weeks, and their relationship with lung injury and bronchopulmonary dysplasia (BPD).

Methods Prospective cross-sectional study of 391 CT-proET-1 measurements (fully automated immunoflorescent assay) from 267 very preterm infants. Measurements were performed at birth (n = 72 infants), on day of life (DOL) 2 (n = 89), on DOL 6 (n = 49), on DOL 28 (n = 106), and at PMA 36 (n = 75). Trial registration: ClinicalTrials.gov NCT01644981.

Results CT-proET-1 values were (median) 151 pmol/L (IQR 118–186) at birth, peaked on DOL 2 (319 pmol/L (235–382)), and declined thereafter to 214 pmol/L (148–293) on DOL 6, 184 pmol/L (149–233) on DOL 28, and 150 pmol/L (118–188) at PMA 36. Infants with BPD had higher CT-proET-1 values on DOL 2 (p = 0.001), DOL 6 (p < 0.001), and DOL 28 (p = 0.007), with no differences at birth and PMA 36 as compared to those without BPD. CT-proET-1 on DOL 6 was significantly correlated with days of mechanical ventilation, nasal CPAP, and oxygen requirement (Spearman’s Rs 0.657, 0.713, 0.745, respectively, p < 0.001 each). Moderate correlations were found for the same parameters on DOL 2 and DOL 28 but not for birth and PMA 36.

Conclusions The levels and the pattern of CT-proET-1 increase during the first week of life might serve as an early marker of BPD.

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