Article Text

PS-172 Serum 25-hydroxyvitamin D In Relation To Lung Function And Exhaled Nitric Oxide In Children
  1. J Huang1,
  2. TC Yao1,
  3. W Yeh1,
  4. S Lai1,
  5. S Liao2,
  6. M Hua2,
  7. M Tsai2,
  8. C Chiu2
  1. 1Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  2. 2Department of Pediatrics, Chang Gung Memorial Hospital, Keelung, Taiwan

Abstract

Background and aims There is increasing evidence that vitamin D plays a role in lung diseases, but it is not clear whether vitamin D is related to lung function and airway inflammation. The objective of this study was to investigate the relationship of vitamin D status with lung function and fraction of exhaled nitric oxide (FeNO) in a population sample of children.

Methods 1,315 children aged 5–18 years were evaluated using serum 25-hydroxyvitamin D [25(OH)D] levels, spirometry, a single-breath online FeNO measurement, and questionnaires.

Results After adjusting for confounders, the mean FVC was 53.7 mL (SE, 26.6 mL; p = 0.043) and the mean FEV1 was 48.6 mL (SE, 23.6 mL; p = 0.040) lower for children with insufficient serum 25(OH)D levels (20–29.9 ng/mL) compared with those with sufficient 25(OH)D levels (≥30 ng/mL). The mean difference between children with deficient (<20 ng/mL) and sufficient levels of serum 25(OH)D was 83.6 mL (SE, 26.7 mL; p = 0.002) for FVC and 56.9 mL (SE, 23.8 mL; p = 0.017) for FEV1. There was no significant association between serum 25 (OH)D levels and FeNO after adjusting for confounders.

Conclusions Our results demonstrate new evidence for a significant relationship between insufficient serum vitamin D levels and worse lung function in children in the community with a suggested dose-response effect. Our findings also suggest that vitamin D status is not a significant determinant of FeNO in children in the general population.

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