Aim Assessment of renal long-term complications in the regional cohort of ELBW children born in 2002–2003.
Methods 40 children (17 born as ELBW infants and 23 full-term control children randomly selected from one GP office) were assessed at the age of 7 years and next prospectively observed up to 11 years. Serum creatinine, Cystatin C, renal ultrasound and 24-hours ambulatory blood pressure measurements (ABPM) were performed.
Results Mean birthweight of the ELBW group equaled 825g, and mean gestational age equaled 26.5 weeks. Mean renal volume at the age of 7 years was: ELBW group - left kidney (LK) 37ml; right kidney (RK) 40ml, control group - LK 59ml; RK 60ml (p < 0.01 for both kidneys). The increase of renal volume between the age of 7 and 11 was similar in both groups. The volume of kidneys at the age of 11 years was: ELBW group - LK 51ml; RK 56ml, control group - LK 67ml; RK 70ml (p < 0.01 for both kidneys). Calculated eGFR values at the age of 7 and 11 years were similar in both groups (ELBV group at the age of 7 and 11 respectively: 124 vs. 123; control group 127 vs. 114 ml/min*1,72m2). The mean arterial blood pressure (ABPM) increased significantly between both time points (ELBW group: 79 vs. 83, control group: 77 vs. 81 mmHg).
Conclusions The smaller renal volume observed in the assessed ELBW children at the age of 7 years persisted up to the age of 11 years, however the renal function seems to be intact.