Background and aims Intrauterine transfusion for rhesus disease is not uncommon, but long-term health and socioeconomic status in adulthood have not previously been reported. This study aimed to compare these outcomes in adult survivors of intrauterine transfusion to that of unaffected siblings.
Methods Participants were adults who received intrauterine transfusion for rhesus disease, and their unaffected sibling (s). Data regarding socioeconomic status, lifestyle and medical history were collected and compared using Chi-squared and T-tests.
Results Affected participants (n = 95) were younger than unaffected (n = 92) (mean ± SD 33.7 ± 9.3 vs 40.1 ± 10.9 years, p < 0.001) and born at lower gestation (34.5 ± 1.6 vs 39.5 ± 2.1 weeks, p < 0.001) but similar in sex distribution (%male: 54% affected vs 45% unaffected, p = 0.21). There were no differences between groups in socioeconomic status and lifestyle variables (Table 1), or health outcomes (Table 2).
Conclusions This study provides the first evidence that survivors of intrauterine transfusion for rhesus disease show no evidence of adverse effects on general health or socioeconomic status in early to middle adulthood.