Article Text

PS-101 New Developments In Autoregulation (ar) Analysis: Assessment Of Causality
  1. J Riera1,
  2. F Cabañas2,
  3. JJ Serrano3,
  4. L Sánchez1,
  5. MC Bravo1,
  6. P López-Ortego1,
  7. R Madero4,
  8. A Pellicer1
  1. 1Neonatology, Hospital Universitario La Paz, IdiPAZ, Universidad Autonoma de Madrid, Madrid, Spain
  2. 2Biomedical Research Foundation, Hospital Universitario La Paz, IdiPAZ, Universidad Autonoma de Madrid, Madrid, Spain
  3. 3Center for Biomedical Technology, Technical University Madrid Spain, Madrid, Spain
  4. 4Statistics, Hospital Universitario La Paz, IdiPAZ, Universidad Autonoma de Madrid, Madrid, Spain


Background Cerebral AR is a complex, developmentally regulated process still not well characterised in neonates. A number of factors interact with the smooth muscle cells regulating cerebral arterial tone and perfusion. Various analytical methods have been applied to explore AR1. Although in this multifactorial process the assessment of synchronicity and causality is crucial, yet it has not been established.

Objective To analyse the temporal causality between two biological signals in the frequency-domain by quantifying the influence of each signal to the other across the frequencies. To assess the predictive capacity of the method to classify infants at risk for adverse neonatal outcome.

Methods Partial directed coherence (PDC)2 and spectral coherence (COH) methods were used to analyse the relationship between spontaneous changes in mean arterial blood pressure (MABP) and near-infrared cerebral oximetry (TOI). PDCMABP»TOI indicated that changes in TOI were induced by MABP changes and PDCTOI»MABP, the opposite.

Results PDCMABP»TOI and PDCTOI»MABP values differed. PDCMABP»TOI and COH predicted low superior vena cava (SVC) flow (≤41 ml/kg per min) with an area under the ROC curve of 0.68 (95% CI: 0.63–0.77; p < 0.001) and 0.60 (95% CI: 0.51–0.70; p < 0.05), respectively; whereas PDCTOI»MABP did not (p < 0.248). The pPDCMABP»TOI and pCOH were calculated as the averaged value per patient. pPDCMABP»TOI but not pCOH predicted mortality.

Conclusions PDCMABP»TOI is a good classifier for infants at risk of brain hypoperfusion and adverse outcome. PDCMABP»TOI allows a non-invasive physiological interpretation of the pressure-AR process in neonates.


  1. Riera J et al. 2014 (submitted)

  2. Baccalá L, Sameshima K. Biol_Cyber 2001.

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