Article Text

PS-094 The Levels Of Bone Alkaline Phosphatase And Human Epidermal Growth Factor Receptor-2 In Patients With Osteosarcoma
  1. J Gajewska1,
  2. J Ambroszkiewicz1,
  3. M Chelchowska1,
  4. T Klepacka2,
  5. M Rychlowska-Pruszynska3
  1. 1Screening Department, Mother and Child Institute, Warsaw, Poland
  2. 2Department of Pathomorphology, Mother and Child Institute, Warsaw, Poland
  3. 3Department of Oncological Surgery for Children and Youth, Mother and Child Institute, Warsaw, Poland

Abstract

Background and aims Osteosarcoma (OS) is a primary malignant bone tumour, deriving from primitive bone-forming mesenchyme and characterised by the production of osteoid tissue or immature bone. The importance of bone alkaline phosphatase (BALP) and human epidermal growth factor receptor-2 (HER-2) as prognostic markers is still discussed. The aim of this study was to investigate serum levels of BALP and HER-2 in patients with OS during clinical treatment.

Methods We studied 22 patients (5 girls, 17 boys) at the age 7–20 years with osteosarcoma treated at the Institute of Mother and Child in Warsaw. All patients were evaluated for the serum levels of BALP and HER-2 before treatment onset, during pre- and postoperative chemotherapy and after termination of treatment. Healthy children (n = 22) were the reference group. The levels of BALP and HER-2 were measured using immunoenzymatic methods.

Results The values of BALP and HER-2 proteins were higher (p < 0.01; p < 0.05) in patients with OS at diagnosis compared with the control group. The values of both markers significantly decreased during chemotherapy in most patients with remission. After therapy, the activity of BALP was higher in patients with progression than with remission of disease (p < 0.001).

Conclusions Our results demonstrate different pattern of BALP and HER-2 proteins during clinical treatment. However, low values of both markers during therapy may characterise remission of disease and favourable prognosis for patients with OS. Further longitudinal studies are necessary to confirm the prognostic values of BALP and HER-2 proteins in this group of patients.

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