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PS-038 Final Height In Patients With Type 1 Diabetes
  1. AL Rodrigues1,
  2. J Extreia2,
  3. D Amaral3,
  4. R Pina3,
  5. C Limbert3,
  6. L Lopes3
  1. 1Serviço de Pediatria, Hospital Divino Espírito Santo, Ponta Delgada, Portugal
  2. 2Serviço de Pediatria, Centro Hospitalar Barreiro Montijo EPE, Lisboa, Portugal
  3. 3Unidade de Endocrinologia, Hospital Dona Estefânia Centro Hospitalar Lisboa Central, Lisboa, Portugal

Abstract

Background Type 1 Diabetes Mellitus (T1DM) is the most common metabolic disease in children. Growth parameters are important indicators of child´s health.

Objective To evaluate final height of patients with T1DM correlating the metabolic control and disease duration with growth and puberty.

Subjects and methods Retrospective analysis of a cohort of adolescents, aged between 15 and 18 years, with T1DM, followed up to final height at a tertiary Hospital clinic. The variables collected were: age, sex, height at diagnosis, final height, parents’ height, pubertal height gain, metabolic control during puberty (mean A1cHB). Statistical analysis was performed using SPSS®v20; results are presented as mean ± SD.

Results Forty six adolescents were included [59% male (M), 41% female (F)]. Mean age at diagnosis was 9.3 ± 3.5 years. Mean A1cHB was 8.15 ± 1.4. In 26 patients, T1DM was diagnosed before puberty; in these, the age at the onset of puberty was 10.8 ± 1.5 (M) and 9.2 ± 0.6 SD years (F). Height SDS at diagnosis was 0.5 ± 1.5 (M) and 0.35 ± 1.2 (F). Final height was -0.2 ± 1 (M) 0.08 ± 0.9 (F). Target height was -0.29 ± 1.1 (M) -0.02 ± 1 (F). Patients were significantly taller than their parents at diagnosis (p = 0,03), and lost height during follow up to final height (p = 0,004) yet final height was within target height (p = 0,3). There was no correlation between final height and metabolic control (p = 0,9) or duration of diabetes (p = 0,4).

Conclusion In spite of a taller stature at diagnosis and variable metabolic control, final height was not compromised, arguing against growth compromise being a major hallmark of deficient metabolic control.

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