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PS-020 Cardiac Function In Newborns With Fetal Growth Restriction: Morphological And Functional Changes
  1. L Rodriguez Guerineau1,
  2. M Perez Cruz2,
  3. FJ Cambra1,
  4. O Gómez2,
  5. J Carretero3,
  6. MD Gomez Roig2,
  7. F Crispi2,
  8. J Bartrons3
  1. 1Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain
  2. 2Department of Obstetrics and Gynecology, Barcelona Center for Maternal Fetal and Neonatal Medicine Hospital Clínic and Hospital Sant Joan de Déu, Barcelona, Spain
  3. 3Pediatric Cardiology, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain

Abstract

Background and aims The adaptive changes of the fetal heart in fetal growth restriction (FGR) could persist into childhood and be responsible for the increased cardiovascular mortality rate in adulthood. The aim of the study was to assess cardiac morphology and function in newborns with FGR.

Methods FGR was defined as a birth weight centile ≤ 10. Prospective study of 50 neonates, 25 with FGR and 25 with normal intrauterine growth and weight at birth (Table 1). Comprehensive echocardiographic study was performed assessing cardiac morphology, systolic and diastolic function.

Results Compared with controls, neonates with FGR had more globular cardiac ventricles (Table 1), lower systolic excursions of the tricuspid and mitral valvular plane and lower values of the s’ in the lateral and septal mitral annulus in the tissue Doppler imaging (TDI) study (p < 0,05). The e’ at the tricuspid, lateral and septal mitral annulus together with the E wave of tricuspid inflow were significantly reduced in the FGR group; and tricuspid deceleration time showed a trend to increase without reaching statistical significance.

Conclusions Newborns with FGR manifest cardiac shape changes, reduced systolic values of the TDI at the left heart and lower values of diastolic function more pronounced at the right heart compared with neonates with normal intrauterine growth.

Abstract PS-020 Table 1

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