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PS-005 The Effect Of Body Composition Changes On Bone Matabolism In Adolescents With Anorexia Nervosa
  1. N Paunovic1,
  2. V Bembo2,
  3. V Culafic-Vojinovic1
  1. 1Endocrinology Division Internal Medicine Department, Railway Helath Care Institute, Belgrade, Serbia
  2. 2Department of Pediatrics and Neonatology, Hospital in Fondi ASL Latina, Fondi Latina, Italy

Abstract

Background The correlation between body composition changes, osteopenia and alterations of leptin, Insulin-like-Growth Factor-1(IGF-1) and cortisol levels has been previously found in patients with anorexia nervosa (AN).

Objective The aim of this study was to investigate the relationship between bone formation (osteocalcin-OC) and bone resorption markers (BetaCrossLaps-BCL) and changes in bone mineral density (BMD), body mass index (BMI), body fat percentage (BF%), leptin, IGF-1 and cortisol levels.

Methods BMI, spinal Z-score (DXA), BF% and leptin, IGF-1, OC, BCL, cortisol levels were measured in 2 groups of girls: AN (n = 20, age 17.2 ± 0.3 years, amenorrhea duration 21.2 ± 0.4 months) and normal weight (n = 20, age 17.5 ± 0.2 years).

Results BMI (14.2 ± 0.86 vs 20.4 ± 0.86, t = -22.77, p = 0.0009), BF%(5.0 ± 1.5 vs 22.9 ± 2.7, t = -25.79, p = 0.0001), Z score (10.5 vs 30.5, Z = -5.41, p = 0.0006) and levels of IGF-1(308.1 ± 42.6 vs 538 ± 21.6; t = -9.75, p = 0.0007), leptin (10.5 vs 30.5, Z = -5.41, p = 0.0006) and OC (16.0 ± 3.49 vs 37.2 ± 5.34, t = -14.84, p = 0.0002) were significantly lower in AN group while levels of cortisol (713 ± 69.1 vs 451 ± 15.9; t = 11.82, p = 0.0003) and BCL (28.1 vs 12.9, Z = -4.1, p = 0.0004) were higher. In AN group we found: positive correlation between OC and BMI (r = 0.984, p = 0.0008), BF% (r = 0.983, p = 0,0008), Z score (r = 0.967, p = 0.0004), leptin (r = 0.985, p = 0.0001) and IGF-1 levels (r = 0.937, p = 0.0006); negative correlation between OC and cortisol (r = -0.982, p = 0.0005); negative correlation between BCL and BMI (r = -0.764, p = 0.0009), BF% (r = -0.724, p = 0.0001), Z score (r = -0.835, p = 0.0002), leptin (r = -0.777, p = 0.0004) and IGF-1 (r = -0.766, p = 0.0008) and positive correlation between BCL and cortisol (r = 0.815, p = 0.0001).

Conclusion Adolescents with AN have significantly altered body composition, impairment of leptin, IGF-1 and cortisol secretion, alterations in bone turnover and severe osteopenia. There is a correlation between bone turnover markers and Z-score, BMI and BF% in patients with AN. We found a significant relationship between leptin, IGF-1 and cortisol levels and bone turnover markers in AN patients.

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