Article Text

G534(P) Prevention of late onset sepsis and central line associated blood stream infection in preterm infants
  1. V Murthy1,
  2. P Nath1,
  3. M Millar1,
  4. J Morris2,
  5. AK Sinha1,3
  1. 1Neonatal Unit, The Royal London Hospital, Barts Health, London, UK
  2. 2Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
  3. 3Centre for Paediatrics, Barts and the London School of Medicine and Dentistry, London, UK


Late onset sepsis (LOS) and Central line associated blood stream infection (CLA-BSI) remains a major cause of mortality and morbidity in preterm infants. Numerous interventions were introduced between 2007 and 2012, aiming to reduce hospital based infections.

Aim To investigate the effects of hospital wide and local interventions on LOS and CLA-BSI rates in preterm infants born at <32 weeks gestation.

Methods Bed care days (BAPM 2001 standards)and catheter days were obtained from Neonatal database, positive blood cultures were obtained from Microbiology laboratory database.

Results Significant reduction in rates of LOS and CLA-BSI from 2007 to 2012 (Table 1) was observed. Poisson regression methods showed reduction in rates to be related to change in policy of antimicrobial use (p < 0.001), introduction of 2% chlorhexidine for catheter care (p < 0.05), aseptic non touch technique (ANTT) for CLA-BSI (p < 0.01); Trust wide audits and ANTT for LOS rates (p < 0.001).

Abstract G534(P)

Table 1

Conclusions A multifaceted approach involving a change in local health care policy, education, training and surveillance can reduce catheter related infections and late onset sepsis in the Neonatal unit.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.