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Towards evidence based medicine for paediatricians
    1. Correspondence to Dr Bob Phillips, Centre for Reviews and Dissemination, University of York, York YO10 5DD, UK; bob.phillips{at}doctors.org.uk

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    At the threshold

    If you could get a multiplex PCR result back to you within 2 h that told you your hot, grumpy, 2-month-old patient did not have bacteraemia, would you discontinue antibiotics?

    How sure would you need to be of that result—95% certain? 98% certain? 99.5% certain?

    What—in diagnostic analysis speak—would be your ‘threshold’?

    The …

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