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You are the neonatal registrar doing a ward round with your consultant. A preterm 4-week-old infant, who was born at 26 weeks gestation, is on continuous nasal continuous positive airway pressure (NCPAP). This baby is enterally fed with expressed breast milk, and being treated with ranitidine for presumed gastro-esophageal reflux disease.
The consultant questioned the risk of necrotising enterocolitis (NEC) with the use of ranitidine.
Structured clinical question
In preterm infants (patient), does the use of ranitidine (intervention) increase the risk of NEC (outcome)?
Search strategy and outcome
The keywords ‘Premature infant’ ‘NEC’ and ‘Ranitidine’ were used.
Secondary sources: Cochrane: no relevant results.
Primary sources: Pubmed (1980–2013), Embase (1980–2013) and CINAHL (1982–2013) databases were searched. There were 101 articles in Pubmed, 56 articles in Embase and 174 articles in CINAHL. Seven relevant articles were identified. Four articles were excluded (two were commentaries, one was a review article and one studied …