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Arch Dis Child 98:510-514 doi:10.1136/archdischild-2012-303109
  • Original article

Environmental tobacco smoke and asthma exacerbations and severity: the difference between measured and reported exposure

  1. Ruchi Gupta5,6
  1. 1Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, USA
  2. 2Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
  3. 3Center for Management of Complex Chronic Care, Edward Hines Jr. Veterans Affairs Hospital, Hines, Illinois, USA
  4. 4Accreditation Council for Graduate Medical Education, Chicago, Illinois, USA
  5. 5Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
  6. 6Department of Pediatrics, Ann and Robert H Lurie Children's Hospital, Chicago, Illinois, USA
  1. Correspondence to Dr Megan McCarville, Department of Pediatrics, University of Illinois at Chicago, 840 South Wood Street, Room 1410, Chicago, IL 60612, USA; mmegan{at}uic.edu
  • Received 28 September 2012
  • Revised 18 March 2013
  • Accepted 24 March 2013
  • Published Online First 20 April 2013

Abstract

Objective To assess the impact of measured versus reported environmental tobacco smoke (ETS) exposure on asthma severity and exacerbations in an urban paediatric population.

Design We analysed cross-sectional data from the Chicago Initiative to Raise Asthma Health Equity study that followed a cohort of 561 children aged 8–14 with physician-diagnosed asthma between 2003 and 2005. Participant sociodemographic data and asthma symptoms were gathered by parental survey; exposures to ETS were determined by salivary cotinine levels and parent report. Multivariable negative binomial and ordered logistic regressions were used to assess associations between ETS and asthma outcomes.

Results Among 466 children included in our analysis, 58% had moderate or severe persistent asthma; 32% had >2 exacerbations requiring a hospitalisation or an emergency room visit or same day care in the previous year. Half of caregivers reported that at least one household member smoked. In multivariable analyses, salivary cotinine was significantly associated with frequently reported exacerbations in the previous year (adjusted incidence rate ratio=1.39, 95% CI 1.09 to 1.79), but not significantly associated with asthma severity. Reported household smoking was not significantly associated with either asthma severity or frequency of exacerbations.

Conclusions Salivary cotinine was more predictive of asthma exacerbation frequency but caregiver- reported household smoking was not. Use of a nicotine biomarker may be important in both the clinical and research settings to accurately identify an important risk factor for asthma exacerbations.

What is already known on this topic

  • Environmental tobacco smoke is associated with worsened asthma symptoms among children.

  • Assessments of children's environmental tobacco exposure frequently rely on caregiver report.

  • Caregiver reports may misclassify smoking exposure.

What this study adds

  • A biological marker of tobacco exposure, but not caregiver-reported household smoking, predicted frequency of exacerbations.

  • Use of biological marker of environmental tobacco smoke exposure, rather than reported household smoking alone, may lead to improved identification of asthma-related risk factors.

Introduction

About 9.1% of USA children have a diagnosis of asthma.1 More severe or poorly controlled asthma leads to asthma exacerbations2 and to chronic cough or wheezing and worsened lung function.3 More than 60% of asthmatics experienced at least one asthma attack and a third had five or more asthma attacks in the previous year.1 ,4 Incident asthma, wheezing episodes and worsened lung function have been associated with environmental tobacco smoke (ETS) exposure.5–9 Treatment guidelines recommend that asthmatics avoid ETS,3 but most asthmatic children have some ETS exposure.10

The best way to identify ETS exposure is unclear.11 Classifying smoking status by self-report alone may be unreliable because children may have ETS exposure outside their own homes12 ,13 or because caregivers may under-report household smoking.

Cotinine is a nicotine biomarker measurable in the blood, urine or saliva.14–16 Salivary cotinine levels increase with greater exposure to ETS.16–19 Household smoking is associated with higher cotinine levels among asthmatic children.20–23 Many children considered non-exposed to tobacco smoke have elevated cotinine levels.24 ,25 Parental surveys about sources of ETS do not adequately predict children's cotinine levels.26

Further studies are needed to characterise caregiver-reported tobacco exposure's reliability in predicting asthma outcomes. Our objective was to assess the association of measured and reported tobacco exposure with asthma severity and exacerbations in an urban paediatric population.

Methods

Data source and study sample

We used data from the Chicago Initiative to Raise Asthma Health Equity (CHIRAH) study for which the design and procedures have been previously described.27 Between 2004 and 2005, CHIRAH enrolled a cohort of 561 asthmatic children aged 8–14. Participants and their caregivers completed an inperson interview to determine household sociodemographic and psychosocial characteristics, the home environment, and participants’ asthma symptoms. Participants underwent anthropometric and spirometry measurements and had their saliva sampled. We excluded 76 participants missing key data (valid cotinine level, detailed exacerbation data, race/ethnicity, home location and/or body mass index (BMI)), and four children with exceptionally high numbers (≥25) of caregiver-reported asthma exacerbations that were likely errors in data collection or entry. We additionally excluded participants with a salivary cotinine level of >10 ng/ml (n=15, or 2.6% of the CHIRAH cohort) as extremely high cotinine values are more likely to represent active smoking.18 ,28 ,29 Our final sample included 466 children.

This study was approved by the institutional review boards of the Ann and Robert H. Lurie Children's Hospital and Northwestern University.

Outcomes

We used two outcome measures, asthma exacerbation frequency and asthma severity. Asthma exacerbation frequency was assessed by caregiver report to the prompt, ‘Total number of asthma exacerbations requiring hospitalisation, ER [emergency room], or same day medical care in the past 12 months.’ Asthma severity was assessed by the participant's classification based on the National Heart, Lung, and Blood Institute/National Asthma Education and Prevention Program guidelines which divided asthma severity into intermittent or mild-, moderate-, or severe-persistent categories on the basis of symptoms, short-acting β2-agonist use, interference with normal activity, exacerbations requiring systemic corticosteroids in the prior year and, if available, spirometry measurements, available for 71% of the CHIRAH cohort.30

Exposure assessment

We measured exposure to ETS by caregiver report of smoking in the household and by measured salivary cotinine. Household smoking was assessed by caregiver report to the question, ‘Does anyone in your house smoke?’ Saliva was collected with a Quanitsal collection pad (Immunalysis, Pomona, California, USA). Cotinine level was determined using a high-sensitivity immunoassay (Salimetrics, Inc., State College, Pennsylvania, USA). For comparisons of tobacco exposure by report versus by biomarker, we considered participants with salivary cotinine levels greater than or equal to 1 to be exposed to ETS, consistent with prior studies.21

Covariates

Potential confounders were identified from caregiver reports and included child age, sex, race/ethnicity, household income (greater than or less than or equal to $50 000 per year) and access to any asthma controller medication. Because salivary cotinine is negatively associated with BMI,31 we included participant BMIs, categorised into normal or underweight, overweight, and obese (BMI <85th, 85–94th, and ≥95th percentiles, respectively).

Analysis

Our outcomes were: (1) total number of caregiver-reported asthma exacerbations in the previous year and (2) asthma severity in four ordered categories (intermittent, mild persistent, moderate persistent, severe persistent). Our primary predictors were (1) caregiver-reported household smoking as a dichotomous variable and (2) salivary cotinine as a continuous variable. Because cotinine levels were not normally distributed they were log-transformed.

For each outcome, we estimated two multivariable models, one with caregiver-reported smoking as the primary predictor and one with log-transformed cotinine level as the primary predictor, with age, sex, race/ethnicity, household income, controller medicine access and BMI category as covariates. Exacerbation frequency was modelled using negative binomial regressions because exacerbation count data were overdispersed. Asthma severity was modelled using ordered logit models after we verified that the model met the proportional odds assumption.32

We used a two-sided Type I error <5% level to determine statistical significance. STATA SE V.12 (StataCorp LP, College Station, Texas, USA) was used for all data analyses.

Results

Participant characteristics and asthma symptoms

Table 1 displays participants’ demographic, socioeconomic and asthma control characteristics. Participants reported an average of 2.3 exacerbations in the previous year. Most participants had mild or moderate persistent asthma and 63.3% had access to at least one asthma controller medication (table 1).

Table 1

Participant characteristics and asthma control and severity (n=466)

Participants excluded due to missing key data (n=76) or extremely large number of reported exacerbations (n=4) were not significantly different from the study sample in race/ethnicity, household income, reported household smoking, BMI category or asthma severity. Excluded participants were significantly more likely to be in the youngest (8–9 years) and oldest (14–15 years) age categories (χ2=7.94, df=3, p=0.047).

Tobacco exposure

About half (50.4%) of caregivers reported that at least one household member smoked. Participants had a mean cotinine level of 1.44 ng/ml; 69.3% had a cotinine level ≥1, consistent with ETS exposure. Participants with caregiver-reported household smoking had significantly higher cotinine levels than those without caregiver-reported household smoking (geometric mean cotinine level 2.00 vs 1.07, p<0.001). Characteristics of participants with ETS exposure by report or by cotinine level are shown in table 2.

Table 2

Smoke exposure by report and by cotinine level and participant characteristics

Asthma exacerbations and tobacco exposure

In multivariable analysis, cotinine was significantly associated with increased exacerbations (incidence rate ratio (IRR)=1.39, 95% CI 1.08 to 1.78) (table 3), independent of potential confounders. In an identically specified model that included reported smoking in place of cotinine, reported smoking was not significantly associated with exacerbation frequency (IRR=1.04, 95% CI 0.83 to 1.31) (table 3).

Table 3

Effect of ETS on asthma exacerbations and severity

Asthma severity and tobacco exposure

In a multivariable ordered logit regression to predict asthma severity levels, there was no significant association between salivary cotinine and asthma severity, although the CI is in the direction of a positive association (OR 1.47; 95% CI 0.91 to 2.38) (table 3). When reported household smoking was used to predict asthma severity, we found no significant association between reported smoking and asthma severity (OR 0.90; 95% CI 0.63 to 1.3) (table 3).

Discussion

Although objectively measured ETS exposure was significantly associated with exacerbation frequency among asthmatic children, caregiver-reported ETS exposure was not. Salivary cotinine may more accurately characterise children's asthma risks from ETS exposure than caregiver-reports of smoking behaviour. The limited number of studies on asthma-related outcomes that have directly compared the effects of biomarkers of tobacco to those of reported smoking have had mixed findings. Two studies demonstrated that both maternal report of smoking and cotinine levels are associated with asthma exacerbations, lung function, and incidence of asthma or asthma-like symptoms.33 ,34 However, other researchers found that maternal serum cotinine was a better predictor of early life wheezing than parent-reported exposure35 and salivary cotinine was a better predictor of lung function than passive ETS exposure determined by questionnaire.36

Discrepancies between reported smoking and biological measures of tobacco exposure may be due to under-reporting of reported household smoking in the research setting due to social desirability bias or to recall bias. Alternatively, children may have tobacco exposures outside of the home that are unrecognised by caregivers, such as through incursions of smoke from other units in multiunit housing13 or exposures in non-household social settings.25 Our findings add to prior research that suggests that a biological measure of smoking exposure may be an important addition to reports of household smoking in order to accurately classify risk factors for more severe asthma outcomes.

The strengths of our study include a relatively large sample size and a predominantly minority inner-city population who are at a high risk of asthma complications. Our study has several limitations. Cotinine levels may vary due to factors other than tobacco exposure because of variation in nicotine metabolism, although we were able to account for some of these factors, including BMI and race/ethnicity, in our multivariable models.21 We have limited information health services-related variables, such as measures of participants’ access to a usual source of care. A total of 95 participants (17%) were excluded from our analysis which could bias our results, although our comparison of the excluded and included subjects suggests that the two groups do not significantly differ in terms of factors that are likely to bias the results.

Acknowledgments

We would like to thank the CHIRAH team, the Chicago Public Schools, and the schools of the Archdiocese of Chicago.

Footnotes

  • Contributors MM conceptualised the data analysis and research questions, prepared data for analysis, interpreted data, prepared the first draft the article, and incorporated revisions to the draft. She also prepared the edited version submitted for revision. She is the guarantor. M-WS and EO analysed and interpreted the data, wrote the statistical analysis plan, and provided critical revisions to the article. KW was involved in the original study design and data collection and provided critical revisions to the article. RG was involved in the original data collection and interpretation of data and provided critical revisions to the article. All authors provided final approval of the version to be published.

  • Funding Funding Academic Pediatrics Association Young Investigator Award; National Heart, Lung, and Blood Institute (1-U01 HL 72496-1).

  • Competing interests None.

  • Ethics approval Northwestern University Institutional Review Board and the Children's Memorial (now Ann and Robert H Lurie Children's Hospital) Institutional Review Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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