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Paracetamol to induce ductus arteriosus closure: is it valid?
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- Published on: 22 March 2016
- Published on: 22 March 2016What gets lost in translation?Show More
With pleasure we read the article by Allegaert et al(1) on the use of paracetamol for ductus arteriosus closure with high doses of paracetamol (15mg/kg q6h) and the response by Mazer-Amishahi(2). The authors propose to initiate a prospective randomized controlled trial. Before embarking on such a 'Proof of Concept' (POC) study, translational considerations may provide usefull insights.
The considered mode of acti...
Conflict of Interest:
None declared.